van Logten M J
Tijdschr Diergeneeskd. 1977 Feb 1;102(3):164-72.
Foods may contain intentional and unintentional additives. The former group includes, for example, flavours, colouring substances and preservatives, while the latter includes pesticides and mycotoxins. To determine the amount of these substances that are admissible in man, extensive toxicological tests have to be performed with experimental animals to establish a no toxic effect level. Based on the no toxic effect level and applying a safety factor an "acceptable daily intake" (ADI) can be calculated for human beings. The problems outlined in the article are illustrated by several examples, such as the presence of DDT and aflatoxin M1 in milk and of mercury in fish.
食品中可能含有有意添加和无意添加的物质。前者例如包括调味剂、色素和防腐剂，而后者包括农药和霉菌毒素。为了确定人体可接受的这些物质的量，必须用实验动物进行广泛的毒理学试验以确定无毒性作用水平。根据无毒性作用水平并应用安全系数，可以计算出人类的“每日允许摄入量”（ADI）。文章中概述的问题通过几个例子来说明，如牛奶中存在滴滴涕和黄曲霉毒素M1以及鱼类中存在汞。
