Shpakova N M, Sheremet L V
Ukr Biokhim Zh (1978). 1993 Jan-Feb;65(1):69-74.
Development peculiarities of hypertonic cold shock of erythrocytes modified with chlorpromazine were studied, maximum protection effect under cooling of cells is registered when using chlorpromazine in the concentration 7 x 10(-5) M. Spectrin denaturation does not change general pattern of the effect of different concentrations of amphipat on sensitivity of erythrocytes to the cold shock but it sensitizes cells modified by chlorpromazine (7 x 10(-5) M) to the further cooling. Differences between native cells and erythrocytes with denatured spectrin are levelled at higher concentrations of amphypat, certain protective effect being observed at certain values of the medium tonicity.
研究了经氯丙嗪修饰的红细胞高渗冷休克的发展特性，当使用浓度为7×10⁻⁵ M的氯丙嗪时，在细胞冷却过程中记录到最大保护作用。血影蛋白变性不会改变不同浓度两亲分子对红细胞对冷休克敏感性影响的总体模式，但会使经氯丙嗪（7×10⁻⁵ M）修饰的细胞对进一步冷却敏感。在较高浓度的两亲分子下，天然细胞与血影蛋白变性的红细胞之间的差异趋于平缓，在培养基等渗压的特定值时可观察到一定的保护作用。
