Pop V J, de Rooy H A, Vader H L, van der Heide D, van Son M M, Komproe I H
Department of Internal Medicine, St Joseph Hospital Veldhoven, The Netherlands.
Acta Endocrinol (Copenh). 1993 Jul;129(1):26-30. doi: 10.1530/acta.0.1290026.
Microsomal antibodies have been related to postpartum thyroid dysfunction and postpartum depression.
To detect the value of microsomal antibodies during gestation in a random population, as a risk factor for thyroid dysfunction and depression during the postpartum period.
The presence of microsomal antibodies was investigated in a random population of 293 women at 32 weeks' gestation. At the same time, postpartum thyroid function was assessed repeatedly in all women every six weeks up to 34 weeks' postpartum. Postpartum thyroid dysfunction, defined as the presence of abnormal TSH, in combination with abnormal fT4 and/or fT3 values, occurred in 21 women (7.2%) during the postpartum period. Depression was assessed using the Research Diagnostic Criteria without knowing the results of biochemical thyroid function tests. At 32 weeks' gestation there were 27 (9.2%) women with elevated microsomal antibody titres. Compared with microsomal-antibody negative women at 32 weeks' gestation, these women had an RR of 20 for developing postpartum thyroid dysfunction and an RR of 1.7 for developing postpartum depression.
Women with elevated microsomal antibody titres during gestation are particularly at risk for postpartum thyroid dysfunction, but only have a slightly increased risk for postpartum depression.
微粒体抗体与产后甲状腺功能障碍及产后抑郁有关。
在随机人群中检测孕期微粒体抗体的价值，作为产后甲状腺功能障碍和抑郁的危险因素。
在293名妊娠32周的随机女性人群中调查微粒体抗体的存在情况。同时，在产后34周前，对所有女性每六周重复评估一次产后甲状腺功能。产后甲状腺功能障碍定义为促甲状腺激素（TSH）异常，同时游离甲状腺素（fT4）和/或游离三碘甲状腺原氨酸（fT3）值异常，在产后期间有21名女性（7.2%）出现该情况。在不知道生化甲状腺功能测试结果的情况下，使用研究诊断标准评估抑郁情况。妊娠32周时，有27名（9.2%）女性微粒体抗体滴度升高。与妊娠32周时微粒体抗体阴性的女性相比，这些女性发生产后甲状腺功能障碍的相对危险度（RR）为20，发生产后抑郁的RR为1.7。
孕期微粒体抗体滴度升高的女性尤其有发生产后甲状腺功能障碍的风险，但产后抑郁的风险仅略有增加。
