Knorr J R, Ragland R L, Brown R S, Gelber N
Department of Radiology, University of Massachusetts Medical Center, Worcester 01655.
AJNR Am J Neuroradiol. 1993 Jul-Aug;14(4):845-51.
To evaluate patients with known hypogonadotropic hypogonadism, some with known anosmia, for defective rhinocephalon development that resulted in olfactory tract abnormalities, an affliction known as Kallmann syndrome.
Six patients who clinically had hypogonadotropic hypogonadism were examined by MR. Thin coronal images of the interior frontal region were used to determine presence or absence of olfactory tract and to evaluate the olfactory sulci.
Olfactory tracts were not seen in three of the six cases; two of which had hypoplastic olfactory sulci.
T1-weighted MR examination of the inferior frontal region in the coronal plane can help determine whether a patient with hypogonadotropic hypogonadism, with or without clinically evident anosmia, is afflicted with Kallmann syndrome.
评估已知促性腺激素缺乏性性腺功能减退的患者，其中一些患者已知嗅觉缺失，以确定是否存在因嗅脑发育缺陷导致的嗅束异常，即一种称为卡尔曼综合征的疾病。
对6例临床诊断为促性腺激素缺乏性性腺功能减退的患者进行磁共振成像（MR）检查。使用额叶内部区域的薄层冠状位图像来确定嗅束是否存在，并评估嗅沟。
6例中有3例未见到嗅束；其中2例嗅沟发育不全。
冠状面T1加权MR检查额叶下部区域有助于确定促性腺激素缺乏性性腺功能减退的患者（无论有无临床明显的嗅觉缺失）是否患有卡尔曼综合征。
