Iseki K, Osawa A, Fukiyama K
Third Department of Internal Medicine, University of The Ryukyus, Okinawa, Japan.
Am J Kidney Dis. 1993 Aug;22(2):308-13. doi: 10.1016/s0272-6386(12)70323-2.
We analyzed longitudinal data on the cancer mortality rate in chronic dialysis patients and in the general population in Okinawa, Japan. In the general population from 1980 to 1990, the mortality rate has been stable at approximately 1.300 males and 0.897 females per thousand persons year, the male to female ratio being 1.45. In the period from 1971 to 1990, we found 91 (4.6%) patients with cancer in a group of 1,982 (824 females and 1,158 males) chronic dialysis patients; forty-nine of the 91 patient (53.8%) died by April 1, 1991. Using the standard mortality rate in the general population, which was obtained for each sex and age class (0 to 34 years, 35 to 44 years, 45 to 54 years, 55 to 64 years, and > or = 65 years), we calculated the relative risk of death from cancer in dialysis patients. The risk ratio in dialysis patients was significantly increased, being 2.48 (P < 0.05) for males and 3.99 (P < 0.05) for females. The mean (+/- SEM) age at the time of death from cancer in the dialysis group was 60.1 +/- 2.0 years in the males and 60.1 +/- 2.1 years in the females; the males were 6.3 years younger than the general population and the females were 9.3 years younger. The proportion of patients with colon cancer (both sexes) and cancer of the uterus and breast (females) was higher in the dialysis patients than in the general population.
我们分析了日本冲绳慢性透析患者和普通人群癌症死亡率的纵向数据。在1980年至1990年的普通人群中，死亡率一直稳定在每千人年约1.300名男性和0.897名女性，男女比例为1.45。在1971年至1990年期间，我们在1982名（824名女性和1158名男性）慢性透析患者中发现了91名（4.6%）癌症患者；91名患者中有49名（53.8%）在1991年4月1日前死亡。使用按性别和年龄组（0至34岁、35至44岁、45至54岁、55至64岁以及≥65岁）获得的普通人群标准死亡率，我们计算了透析患者癌症死亡的相对风险。透析患者的风险比显著增加，男性为2.48（P<0.05），女性为3.99（P<0.05）。透析组癌症死亡时的平均（±SEM）年龄男性为60.1±2.0岁，女性为60.1±2.1岁；男性比普通人群年轻6.3岁，女性比普通人群年轻9.3岁。透析患者中结肠癌（男女皆有）以及子宫癌和乳腺癌（女性）患者的比例高于普通人群。
