Wiese C, Wilson K L
Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Curr Opin Cell Biol. 1993 Jun;5(3):387-94. doi: 10.1016/0955-0674(93)90002-8.
Our understanding of nuclear membrane trafficking and protein targeting has increased significantly, due to newly developed assays and tools. We present a conceptual framework for thinking about protein targeting to the inner nuclear membrane, and discuss nuclear envelope assembly in terms of vesicle binding to chromatin, vesicle fusion, structural attachments to the inner membrane, and the mitotic regulation of these attachments.
由于新开发的检测方法和工具，我们对核膜运输和蛋白质靶向的理解有了显著提高。我们提出了一个用于思考蛋白质靶向内核膜的概念框架，并从囊泡与染色质的结合、囊泡融合、与内膜的结构附着以及这些附着的有丝分裂调控等方面讨论了核膜组装。
