Ogura C, Nageishi Y, Omura F, Fukao K, Ohta H, Kishimoto A, Matsubayashi M
Department of Neuropsychiatry, School of Medicine, University of Ryukyus, Okinawa, Japan.
Biol Psychiatry. 1993 May 15;33(10):720-6. doi: 10.1016/0006-3223(93)90122-t.
Event-related potentials (ERPs) recorded during a two-tone discrimination (oddball) task were examined in 36 drug-free depressed patients and 36 control subjects. At remission, the ERPs of 12 of the depressed patients were reexamined. In the depressed patients, although a group difference was not detected in the peak latency and amplitude of N200 to rare stimuli, the mean amplitude for the N200 latency range in the difference waves was smaller than in the control subjects. Mismatch negativity (N2a), which was elicited by rare stimuli, was reduced in amplitude; but N2b may have been evoked to frequent stimuli more in the patients than in the control subjects. Depressed subjects may have a deviance in the fully automatic cerebral mismatch process that is assumed to be related to mismatch negativity and provoke the controlled mismatch detection process (presumed to be associated with N2b) even to nontarget frequent stimuli. These findings were observed during remission; however, there was a tendency for the N2b amplitude to decrease and recover toward the level of the control subjects.
在一项双音辨别（异常球）任务中记录的事件相关电位（ERP），在36名未服用药物的抑郁症患者和36名对照受试者中进行了检测。在缓解期，对12名抑郁症患者的ERP进行了重新检测。在抑郁症患者中，虽然在对罕见刺激的N200的峰值潜伏期和波幅方面未检测到组间差异，但差异波中N200潜伏期范围内的平均波幅低于对照受试者。由罕见刺激引发的失配负波（N2a）波幅降低；但在患者中，N2b可能比对照受试者更多地由频繁刺激诱发。抑郁症受试者在完全自动的大脑失配过程中可能存在偏差，该过程被认为与失配负波有关，甚至对非目标频繁刺激也会引发受控的失配检测过程（推测与N2b有关）。这些发现是在缓解期观察到的；然而，N2b波幅有降低并向对照受试者水平恢复的趋势。
