Department of Psychiatry, Washington University, Saint Louis, MO, USA.
Trends Neurosci. 2012 Sep;35(9):527-35. doi: 10.1016/j.tins.2012.04.012. Epub 2012 Jun 2.
A recent paradigm shift in systems neuroscience is the division of the human brain into functional networks. Functional networks are collections of brain regions with strongly correlated activity both at rest and during cognitive tasks, and each network is believed to implement a different aspect of cognition. We propose here that anxiety disorders and high trait anxiety are associated with a particular pattern of functional network dysfunction: increased functioning of the cingulo-opercular and ventral attention networks as well as decreased functioning of the fronto-parietal and default mode networks. This functional network model can be used to differentiate the pathology of anxiety disorders from other psychiatric illnesses such as major depression and provides targets for novel treatment strategies.
系统神经科学最近的一个范式转变是将人类大脑划分为功能网络。功能网络是具有强烈相关性的脑区集合，无论是在休息状态还是在认知任务期间，每个网络都被认为实现了认知的不同方面。我们在这里提出，焦虑障碍和高特质焦虑与特定的功能网络功能障碍模式有关：扣带-脑岛和腹侧注意网络的功能增强，以及额顶叶和默认模式网络的功能降低。这种功能网络模型可用于区分焦虑障碍与其他精神疾病（如重度抑郁症）的病理学，并为新的治疗策略提供目标。
