Blandamura S, Altavilla G, Castoro C, Antonini C, Piazza M
Istituto di Anatomia Patologica, Università di Padova, Italy.
Ital J Gastroenterol. 1993 Jun;25(5):259-64.
The case of a 56-year-old man with contemporary benign granular cell tumour of the oesophagus and stomach is reported. Surgical resection of the oesophagus and stomach was performed after the diagnosis of squamous cell carcinoma on a superficial oesophageal biopsy which showed a pseudo-epitheliomatous hyperplasia of the stratified squamous epithelium covering the oesophageal Granular Cell Tumour (GCT). Hyperplasia was also found in the overlying gastric mucosa. Eight GCTs of the oesophagus, observed between 1980 and 1985, were reevaluated to compare the neoplastic characteristics and the occurrence of overlying epithelial hyperplasia. Only one patient was female; three had multiple oesophageal tumours and four showed pseudo-epitheliomatous hyperplasia. A review of the literature is included with emphasis on the rare cases of multiple GCTs. The association of chronic alcoholism with GCT of the gastro-intestinal tract is also stressed.
报告了一例56岁男性患有食管和胃的当代良性颗粒细胞瘤的病例。在对食管浅表活检诊断为鳞状细胞癌后进行了食管和胃的手术切除，活检显示覆盖食管颗粒细胞瘤（GCT）的复层鳞状上皮呈假上皮瘤样增生。在上覆胃黏膜中也发现了增生。对1980年至1985年间观察到的8例食管GCT进行重新评估，以比较肿瘤特征和上覆上皮增生的发生率。仅1例患者为女性；3例有多个食管肿瘤，4例显示假上皮瘤样增生。文中包含文献综述，重点关注罕见的多发GCT病例。还强调了慢性酒精中毒与胃肠道GCT的关联。
