哺乳动物染色体结构。

Mammalian chromosome structure.

作者信息

Tyler-Smith C, Willard H F

机构信息

Department of Biochemistry, University of Oxford, UK.

出版信息

Curr Opin Genet Dev. 1993 Jun;3(3):390-7. doi: 10.1016/0959-437x(93)90110-b.

DOI:10.1016/0959-437x(93)90110-b

PMID:8353411

Abstract

The DNA sequences that are necessary for the formation of a functional mammalian chromosome are thought to be the origins of replication, the telomeres and the centromere. Telomere structure is now well understood, with the functional element characterized as the motif (TTAGGG)n. The structures of the DNA regions that contain origins of replication and a centromere are known, but the functionally important elements within these regions are still only poorly defined.

摘要

形成功能性哺乳动物染色体所必需的DNA序列被认为是复制起点、端粒和着丝粒。现在对端粒结构已经有了很好的了解，其功能元件被确定为基序(TTAGGG)n。包含复制起点和着丝粒的DNA区域的结构是已知的，但这些区域内功能上重要的元件仍然定义不清。