Claiborne B J, Xiang Z, Brown T H
Division of Life Sciences, University of Texas, San Antonio 78249.
Hippocampus. 1993 Apr;3(2):115-21. doi: 10.1002/hipo.450030202.
Much of the current interest in the hippocampus concerns a rapid and persistent form of synaptic plasticity, called long-term potentiation (LTP), that is a candidate substrate for some of the mnemonic functions of this structure. There are at least two kinds of LTP in the hippocampus. One form is found at the synapse between the mossy fibers of the granule cells and the pyramidal neurons of the CA3 region. Attempts to examine the mechanism underlying this form of LTP have yielded contradictory conclusions. The authors show how the complex circuitry of the dentate gyrus and adjacent hippocampus may have caused the contradictions. To overcome problems introduced by the circuitry, a specific set of procedures and criteria for evoking and identifying mossy fiber responses is proposed. Use of these or similar procedures and criteria will improve the design and interpretation of experiments on mossy fiber LTP and allow more informative comparisons among species and brain regions and across laboratories.
目前对海马体的诸多关注都集中在一种快速且持久的突触可塑性形式上，即长时程增强（LTP），它是该结构某些记忆功能的潜在底物。海马体中至少存在两种LTP。其中一种形式存在于颗粒细胞的苔藓纤维与CA3区的锥体神经元之间的突触处。试图探究这种LTP形式背后机制的研究得出了相互矛盾的结论。作者展示了齿状回和相邻海马体的复杂回路是如何导致这些矛盾的。为克服回路带来的问题，提出了一套用于诱发和识别苔藓纤维反应的特定程序及标准。使用这些或类似的程序和标准将改进苔藓纤维LTP实验的设计和解释，并允许在物种、脑区之间以及不同实验室之间进行更具信息量的比较。
