McNamara R K, Kirkby R D, dePape G E, Skelton R W, Corcoran M E
Department of Psychology, University of Victoria, British Columbia, Canada.
Hippocampus. 1993 Apr;3(2):149-52. doi: 10.1002/hipo.450030207.
There is some controversy about the role of long-term potentiation (LTP) in spatial learning. The authors have found that triggering generalized kindled seizures with stimulation of the perforant path disrupts spatial learning in the Morris water maze but that kindling per se does not affect spatial learning. It is suggested that abnormal electrical activity induced by high-frequency stimulation of the perforant path may have been responsible for the disruption of spatial learning previously attributed to LTP saturation.
关于长时程增强（LTP）在空间学习中的作用存在一些争议。作者发现，通过刺激穿通路径引发全身性点燃性癫痫发作会扰乱莫里斯水迷宫中的空间学习，但点燃本身并不影响空间学习。有人认为，先前归因于LTP饱和导致的空间学习破坏可能是由穿通路径高频刺激诱发的异常电活动所致。
