Barta E, Cornák V, Pechán I, Luknárová O, Verchovodko P, Rendeková V
Ustav kardiovaskulárnych chorôb v Bratislave, Slovakia.
Bratisl Lek Listy. 1993 Jan;94(1):17-23.
Investigation of cardiosurgical patients have provided evidence for the generation of free oxygen radicals during open heart surgery. The finding of increased plasma malondialdehyde concentrations, considered to be an indicator of lipid peroxidation in cell membranes, is suggestive of this process. Simultaneously, the antiradical capacity of tissue was found to exhibit a decreasing trend, as established by the levels of superoxide dismutase and catalase in erythrocytes of peripheral blood which tended to diminish. The funding that no changes in the studied parameters were observed in the blood from the coronary sinus taken before and after interruption of coronary blood flow demonstrates that the commonly applied protection of the myocardium by hypothermic cardioplegic solution and topical cooling of the heart is effective in suppressing radical formation. (Fig. 5, Ref. 36.)
对心脏外科手术患者的研究为心脏直视手术期间游离氧自由基的产生提供了证据。血浆丙二醛浓度升高这一发现被认为是细胞膜脂质过氧化的指标，提示了这一过程。同时，通过外周血红细胞中超氧化物歧化酶和过氧化氢酶水平趋于降低的情况确定，组织的抗自由基能力呈现下降趋势。在冠状动脉血流阻断前后采集的冠状窦血液中未观察到研究参数的变化，这一发现表明，常用的低温心脏停搏液保护心肌和心脏局部降温在抑制自由基形成方面是有效的。（图5，参考文献36。）
