Pechán J, Cesnaková Z, Balazovjech I
I. interná klinika LFUK a FN v Bratislave, Slovakia.
Bratisl Lek Listy. 1993 Jan;94(1):33-6.
The microcirculation of the subcutaneous tissue and muscles of the extremities is changed already in the early stage of essential hypertension. Insight into the effect of celiprolol, a beta blocker of the third generation, on tissue microcirculation is of both pathogenetic and therapeutic value. On using the method of Na131I tissue clearance, the effect of celiprolol on the microcirculation of subcutaneous tissue and muscles of the extremities was studied in 21 patients with essential hypertension. Celiprolol was administered orally in the daily dose of 300 mg. After one-week administration celiprolol significantly reduced mean arterial pressure and significantly increased the microcirculation in the subcutaneous tissue of the hand and crus as well as in the calf muscle. Celiprolol was thus found to increase the microcirculation in those tissues of the extremities in which its decrease was recorded before onset of the treatment. The obtained results may be of therapeutic value particularly in patients suffering from ischemia of the lower extremities. (Fig. 2, Ref. 19.).
在原发性高血压的早期阶段，四肢皮下组织和肌肉的微循环就已发生改变。了解第三代β受体阻滞剂塞利洛尔对组织微循环的影响具有病因学和治疗学价值。采用¹³¹碘钠组织清除法，对21例原发性高血压患者研究了塞利洛尔对四肢皮下组织和肌肉微循环的影响。塞利洛尔口服给药，日剂量为300毫克。给药一周后，塞利洛尔显著降低平均动脉压，并显著增加手部和小腿皮下组织以及小腿肌肉的微循环。因此发现，塞利洛尔可增加四肢那些在治疗前记录到微循环减少的组织的微循环。所得结果可能具有治疗价值，尤其对于患有下肢缺血的患者。（图2，参考文献19。）
