Tuveri M A, Passiu G, Mathieu A, Aloe L
II Chair of Rheumatology, University of Cagliari, Italy.
Clin Exp Rheumatol. 1993 May-Jun;11(3):319-22.
Nerve growth factor (NGF), a well-characterized neurotrophic factor, induces an increase in the number of mast cells (MCs) in the peripheral tissues of developing rats, as well as histamine release in fully differentiated MCs. Since MCs increase in the dermis of patients with early systemic sclerosis (SSc), we examined the distribution of NGF in the skin of patients affected by SSc. Immunohistochemical studies showed that NGF distribution was more intense in the dermis of patients with SSc than in the skin of controls. A possible correlation between MCs and NGF in disease activity is hypothesized.
神经生长因子（NGF）是一种特征明确的神经营养因子，可诱导发育中大鼠外周组织中肥大细胞（MC）数量增加，以及在完全分化的MC中组胺释放。由于早期系统性硬化症（SSc）患者真皮中的MC数量增加，我们研究了NGF在SSc患者皮肤中的分布。免疫组织化学研究表明，SSc患者真皮中NGF的分布比对照组皮肤中更强烈。推测疾病活动中MC与NGF之间可能存在相关性。
