Lin Q D
Ren Ji Hospital of Shanghai Second Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1993 Mar;28(3):143-6, 188.
One hundred and fourty-eight cases of habitual abortion were screened for etiologies. We found 40.5% (60/148) were unexplained. Among them, 34 cases were volunteers for receiving repeated active immunolization with low-dose of lymphocyte from their husbands or other donors, and 12 cases were taken as control. The successful pregnant rate was 86.4% (19/22) in treatment group which is higher significantly than in control (P < 0.05). meanwhile, used by microlymphocytotoxic antibody test and one-way mixed lymphocyte reaction and its inhibition test, the observations on immunologic state before and after vaccination were made in 19 cases. We found both the positive rate of microlymphocytotoxic antibody test and the relative suppressive rate of lymphocyte response were increased significantly post-vaccination than pre-vaccination. These results not only confirmed that active immunization was effective, but also suggested that habitual abortion may be associated with the lack of protective antibody and/or block antibody.
对148例习惯性流产病例进行了病因筛查。我们发现40.5%（60/148）病因不明。其中，34例自愿接受来自其丈夫或其他供体的低剂量淋巴细胞反复主动免疫，12例作为对照。治疗组成功妊娠率为86.4%（19/22），显著高于对照组（P<0.05）。同时，采用微量淋巴细胞毒抗体试验、单向混合淋巴细胞反应及其抑制试验，对19例接种前后的免疫状态进行了观察。我们发现，接种后微量淋巴细胞毒抗体试验阳性率和淋巴细胞反应相对抑制率均较接种前显著提高。这些结果不仅证实了主动免疫是有效的，而且提示习惯性流产可能与保护性抗体和/或封闭抗体缺乏有关。
