Coffey T J, Dowson C G, Daniels M, Spratt B G
Microbial Genetics Group, School of Biological Sciences, University of Sussex, Brighton, UK.
FEMS Microbiol Lett. 1993 Jul 1;110(3):335-9. doi: 10.1111/j.1574-6968.1993.tb06345.x.
The region encoding the transpeptidase domain of the penicillin-binding protein 2B (PBP 2B) gene of two penicillin-resistant clinical isolates of Streptococcus oralis was > 99.6% identical in nucleotide sequence to that of a penicillin-resistant serotype 6 isolate of Streptococcus pneumoniae. The downstream 849 base pairs of these genes were identical. Analysis of the data indicates that the PBP gene has probably been transferred from S. pneumoniae into S. oralis, rather than vice versa, and shows that one region of this resistance gene has been distributed horizontally both within S. pneumoniae and into two different viridans group streptococci.
口腔链球菌的两株耐青霉素临床分离株中，编码青霉素结合蛋白2B（PBP 2B）基因转肽酶结构域的区域，其核苷酸序列与肺炎链球菌的一株耐青霉素6型分离株的该区域有> 99.6%的同一性。这些基因下游的849个碱基对是相同的。数据分析表明，PBP基因可能是从肺炎链球菌转移至口腔链球菌，而非相反，并且表明该耐药基因的一个区域已在肺炎链球菌内以及两种不同的草绿色链球菌群之间水平传播。
