Ho K J, Bondi J L
Am J Clin Nutr. 1977 Feb;30(2):151-9. doi: 10.1093/ajcn/30.2.151.
Compartmental analysis of the disappearance curve of serum cholesterol specific activity after an intravenous administration of a tracer does of cholesterol-4-14C was carried out in five patients with resection of the distal small intestine, cecum, and proximal colon. The data fit best a two compartment model in all five cases with the rapidly exchangeable pool of 16.6+/-3.2 g (mean +/- SD, 60% of the mean of 15 normal subjects) and the slowly exchangeable pool of 31.5 +/- 10.9 g (65%). The reduction of the pool sizes was associated with a shorter mean transit time of cholesterol, 22.15 +/- 8.07 days (40%) and increased turnover rate, 2.42 +/- 0.72g/ day (172%). Direct fecal analysis for the neutral sterols and bile acids derived from the exchangeable pool confirmed the turnover rate obtained from the compartmental analysis. The increased fecal excretion was mainly in the bile acid fraction. The study suggests that the ileal and proximal colon resection results in bile acid malabsorption which, in turn, increases hepatic cholesterol and bile acid synthesis. The synthetic rates, however, could not compensate totally for the excretory rate. Therefore, the pool size decreased to a new low steady state of equilibrium.
对5例远端小肠、盲肠和近端结肠切除患者静脉注射胆固醇 - 4 - 14C示踪剂量后血清胆固醇比活消失曲线进行了房室分析。在所有5例患者中，数据最符合二房室模型，快速可交换池为16.6±3.2g（均值±标准差，为15名正常受试者均值的60%），缓慢可交换池为31.5±10.9g（65%）。池大小的减少与胆固醇平均转运时间缩短有关，为22.15±8.07天（40%），周转速率增加，为2.42±0.72g/天（172%）。对来自可交换池的中性固醇和胆汁酸进行直接粪便分析，证实了房室分析得出的周转速率。粪便排泄增加主要在胆汁酸部分。该研究表明，回肠和近端结肠切除导致胆汁酸吸收不良，进而增加肝脏胆固醇和胆汁酸合成。然而，合成速率不能完全补偿排泄速率。因此，池大小降至新的低稳态平衡。
