Gueux E, Cubizolles C, Bussière L, Mazur A, Rayssiguier Y
Centre de Recherches en Nutrition Humaine, INRA, St-Genès-Champanelle, France.
Lipids. 1993 Jun;28(6):573-5. doi: 10.1007/BF02536092.
Hypertriglyceridemia observed in magnesium (Mg)-deficient rats was associated with a significant increase in the very low-density lipoprotein (VLDL) plus low-density lipoprotein (LDL) fractions. The results from in vitro copper-induced lipid peroxidation, expressed in terms of conjugated dienes and thiobarbituric acid reactive substances content, showed that VLDL + LDL particles from Mg-deficient rats were more susceptible to oxidative damage than lipoproteins from control rats. These results suggest that the mechanism responsible for the atherogenicity and tissue damage characteristic of Mg deficiency may be mediated by an increased susceptibility of triglyceride-rich lipoproteins to peroxidation in hypertriglyceridemic animals.
在缺镁大鼠中观察到的高甘油三酯血症与极低密度脂蛋白（VLDL）加低密度脂蛋白（LDL）组分的显著增加有关。体外铜诱导的脂质过氧化结果，以共轭二烯和硫代巴比妥酸反应性物质含量表示，表明来自缺镁大鼠的VLDL + LDL颗粒比来自对照大鼠的脂蛋白更容易受到氧化损伤。这些结果表明，缺镁的致动脉粥样硬化性和组织损伤特征的机制可能是由高甘油三酯血症动物中富含甘油三酯的脂蛋白对过氧化的敏感性增加介导的。
