转录活性核小体内DNA的灵活性：通过圆二色性测量进行分析

Flexibility of DNA within transcriptionally active nucleosomes: analysis by circular dichroism measurements.

作者信息

Krajewski W A, Panin V M, Razin S V

机构信息

Laboratory of Biochemistry, Russian Academy of Sciences, Moscow.

出版信息

J Biomol Struct Dyn. 1993 Jun;10(6):1001-11. doi: 10.1080/07391102.1993.10508692.

DOI:10.1080/07391102.1993.10508692

PMID:8357538

Abstract

The conformational flexibility of DNA in transcriptionally active chromatin fractions has been estimated by circular dichroism spectroscopy analysis and was found to be restricted in the same fashion as in bulk chromatin. The observation is discussed in the context of different models of active chromatin organization.

摘要

通过圆二色光谱分析估计了转录活性染色质组分中DNA的构象灵活性，发现其受到限制的方式与整体染色质相同。在活性染色质组织的不同模型背景下讨论了这一观察结果。