Takahashi T, Fukai T, Hata H, Kasuya H, Kuga T, Egashira K, Takeshita A
Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Cardiovasc Drugs Ther. 1993 Apr;7(2):265-71. doi: 10.1007/BF00878517.
The effects of a new calcium antagonist, CD-832, on experimental coronary artery spasms were studied in Göttingen miniature pigs. Pigs underwent endothelial denudation at the left anterior descending coronary artery using a balloon catheter. Changes in the diameter of the denuded and nondenuded site in response to an intracoronary administration of serotonin (10 micrograms/kg) or histamine (10 micrograms/kg) were assessed quantitatively by selective coronary arteriography 1 week after endothelial denudation. Percent reductions of the coronary artery diameter induced by serotonin or histamine in the denuded site were significantly greater than those in the nondenuded site (p < 0.01). Coronary artery spasm induced by serotonin or histamine in the denuded site was attenuated in a dose-dependent manner by intravenous infusion of CD-832 (10 and 30 micrograms/kg/min) or nifedipine (1 and 3 micrograms/kg/min). The degrees of inhibition of coronary artery spasm by CD-832 were similar to those produced by nifedipine. CD-832 and nifedipine at the high dose caused comparable increases in the basal coronary artery diameter. These results suggest that CD-832 may be a useful drug for the treatment of coronary artery spasm.
在哥廷根小型猪中研究了一种新型钙拮抗剂CD - 832对实验性冠状动脉痉挛的影响。使用球囊导管对猪的左前降支冠状动脉进行内皮剥脱。在内皮剥脱1周后，通过选择性冠状动脉造影定量评估冠状动脉内给予血清素（10微克/千克）或组胺（10微克/千克）后，剥脱部位和未剥脱部位直径的变化。血清素或组胺在剥脱部位引起的冠状动脉直径减少百分比显著大于未剥脱部位（p < 0.01）。静脉输注CD - 832（10和30微克/千克/分钟）或硝苯地平（1和3微克/千克/分钟）可使血清素或组胺在剥脱部位诱导的冠状动脉痉挛以剂量依赖方式减轻。CD - 832对冠状动脉痉挛的抑制程度与硝苯地平相似。高剂量的CD - 832和硝苯地平可使基础冠状动脉直径产生相当的增加。这些结果表明，CD - 832可能是一种治疗冠状动脉痉挛的有用药物。
