用于分析齐哌西定的气相色谱-质谱联用（GC-MS）方法
GC-MS procedure for the analysis of zipeprol.
作者信息
Kintz P, Flesch F, Jaeger A, Mangin P
机构信息
Institut de Médecine Légale, Strasbourg, France.
出版信息
J Pharm Biomed Anal. 1993 Apr-May;11(4-5):335-8. doi: 10.1016/0731-7085(93)80025-v.
A sensitive and specific quantitative method for the determination of zipeprol, a newly abused antitussive, in human fluids is described. Zipeprol and an internal standard, levallorphan, are isolated by a basic extraction and back-extraction process. The final extract is derivatizated with BSTFA + 1% TMCS and separated on a 12-m HP-1 capillary column. Drugs are detected by selected ion monitoring at m/z 335 and m/z 355 for zipeprol and the internal standard, respectively. The minimum detectable quantities are 0.6 and 0.4 ng ml-1, for zipeprol in plasma and urine, respectively. Relative standard deviations for within-run data are less than 6%.
本文描述了一种灵敏且特异的定量方法，用于测定人体体液中新型滥用止咳药齐帕特罗。齐帕特罗和内标左洛啡烷通过碱提取和反萃取过程进行分离。最终提取物用BSTFA + 1% TMCS进行衍生化，并在12米的HP-1毛细管柱上分离。分别通过选择离子监测在m/z 335和m/z 355处检测齐帕特罗和内标药物。血浆和尿液中齐帕特罗的最低检测量分别为0.6和0.4 ng ml-1。批内数据的相对标准偏差小于6%。
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