Gauto A, Law E J, Holder I A, MacMillan B G
Am J Surg. 1977 Feb;133(2):174-8. doi: 10.1016/0002-9610(77)90074-5.
Systemic candidiasis has emerged as a major cause of death in burn patients. An increase both in the incidence of systemic candidiasis and its increase as a cause of death has been observed. Treatment with systemic amphotericin-B prior to 1971 at our institution was rarely successful. This was felt to be in part due to lack of sufficiently early recognition of the infection and to delay in the initiation of appropriate systemic therapy. From 1971 to 1975, fifteen patients have been treated with systemic amphotericin-B with one death. There have been no fatalities from candidiasis since 1972. No serious complications attributed to the use of amphotericin-B were observed. Prompt initiation of therapy with intravenous amphotericin-B is advised for burn patients in whom systemic candidiasis is present.
全身性念珠菌病已成为烧伤患者死亡的主要原因。全身性念珠菌病的发病率及其作为死亡原因的比例均有所上升。1971年以前，我们机构使用全身性两性霉素B进行治疗很少成功。这部分被认为是由于对感染缺乏足够早的认识以及启动适当的全身治疗存在延迟。1971年至1975年，15例患者接受了全身性两性霉素B治疗，1例死亡。自1972年以来，念珠菌病无死亡病例。未观察到因使用两性霉素B引起的严重并发症。对于存在全身性念珠菌病的烧伤患者，建议及时开始静脉注射两性霉素B治疗。
