Iijima S, Otsuka F
Department of Dermatology, Mito Red Cross Hospital, Japan.
Dermatology. 1993;187(2):115-8. doi: 10.1159/000247219.
The efficacy of squaric acid dibutylester (SADBE), a topical allergen, was investigated in the treatment of 20 patients with warts. All patients had multiple or warts recalcitrant to other therapies or hesitated to have the painful cryotherapy. The patients with warts present for a mean of 15.3 months (range 1-36) were successfully sensitized with 2% SADBE in acetone. Then the warts were treated with a 0.1 or 0.01% SADBE application once a week or every other week, so as to maintain a mild contact dermatitis. Twelve of the 20 patients (60%) were completely cured after an average of 6 applications (range 2-12). Five patients (25%) showed either a poor or no response even after 9-18 applications. Three patients (15%) exhibited contact dermatitis either at the sensitization or the treatment site. Our study shows that this therapy, although not always safe, is effective in treating warts in some patients, who either hesitate at conventional cryotherapy or have warts resistant to other therapies. The safety of this method remains to be evaluated.
对一种外用变应原——二丁基酒石酸酯（SADBE）治疗20例疣患者的疗效进行了研究。所有患者均有多个疣或对其他治疗方法顽固不愈，或不愿接受痛苦的冷冻疗法。疣出现的平均时间为15.3个月（范围1 - 36个月）的患者用2%的SADBE丙酮溶液成功致敏。然后用0.1%或0.01%的SADBE每周或每隔一周治疗一次疣，以维持轻度接触性皮炎。20例患者中有12例（60%）平均经过6次治疗（范围2 - 12次）后完全治愈。5例患者（25%）即使经过9 - 18次治疗，反应也很差或无反应。3例患者（15%）在致敏或治疗部位出现接触性皮炎。我们的研究表明，这种疗法虽然并非总是安全的，但对一些对传统冷冻疗法犹豫不决或疣对其他治疗有抵抗性的患者治疗疣是有效的。这种方法的安全性仍有待评估。
