用23Na核磁共振波谱法研究强心苷引起的人红细胞内钠离子浓度升高：心肌收缩力速度与细胞内钠离子浓度升高速率之间的关系
Cardiac glycoside-induced elevation of intracellular Na+ ion concentration in human erythrocytes studied by 23Na NMR spectroscopy: relationship between inotropy speed and elevation rate of intracellular Na+ ion concentration.
作者信息
Tanase T, Murakami N, Nagatsu A, Sakakibara J
机构信息
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
出版信息
Biol Pharm Bull. 1993 Apr;16(4):431-3. doi: 10.1248/bpb.16.431.
PMID:8358396
Abstract
Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin, and its four derivatives was measured using 23Na NMR spectrometry. In this examination, there was a significant correlation between the time to half maximum inotropic effect and the time to maximum of Na+ concentrations in human erythrocyte, determined by 23Na NMR.
摘要
使用23Na核磁共振光谱法测量了强心苷海葱苷元及其四种衍生物诱导的人红细胞内钠离子浓度的升高。在这项检测中，通过23Na核磁共振测定的达到最大变力效应一半的时间与人红细胞中钠离子浓度达到最大值的时间之间存在显著相关性。
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