Elmes P J
Am J Vet Res. 1977 Jan;38(1):107-12.
Three preparations were made of the bovine digit: isolated, spirally cut digital arteries and veins; pump (Ringer's)-perfused, isolated digit; and pump (blood)-perfused digit of the intact anesthetized calf. Administration of histamine, serotonin (5-hydroxytryptamine), phenylephrine, bradykinin, and prostaglandin F2alpha in general caused vasoconstriction. Preparations vasodilated in response to isoproterenol and prostaglandins E1 and E2. Epinephrine and isoproterenol caused biphasic effects in the isolated vein, but consistently produced only vasoconstriction in the perfused systems. Preparations taken from calves previously sensitized to horse serum mounted antigen-specific vasoconstrictor responses upon antigenic challenge. Responses of hoof vasculature to neurohormones and to antigen are consistent with a specific local allergic vascular response as a pathologic entity and may contribute to the understanding of the vascular changes implicated in laminitis.
分离出螺旋状切割的趾动脉和静脉；用泵（林格氏液）灌注的离体牛蹄；以及对完整麻醉小牛用泵（血液）灌注的牛蹄。一般来说，组胺、血清素（5-羟色胺）、去氧肾上腺素、缓激肽和前列腺素F2α的给药会引起血管收缩。这些制备物对异丙肾上腺素、前列腺素E1和E2有血管舒张反应。肾上腺素和异丙肾上腺素在离体静脉中产生双相效应，但在灌注系统中始终只产生血管收缩作用。取自先前对马血清致敏的小牛的制备物在抗原攻击时会产生抗原特异性血管收缩反应。蹄部血管对神经激素和抗原的反应与作为一种病理实体的特异性局部过敏性血管反应一致，可能有助于理解与蹄叶炎相关的血管变化。
