Grenier J, Serrou B, Suquet P, Pujol H
Pathol Biol (Paris). 1978 Sep;26(6):371-2.
A variety of markers have been used in the surveillance of carcinoma of the breast and malignant melanoma, including carcino-embryonic antigen (CEA) beta2-microglobulin (beta2m) and prolactin. The dual purpose of the surveillance was the detection of early recurrence or metastasis and the monitoring of the treatment. In cancer of the breast 92% of patients having bone metastases have elevated levels of CEA or beta2m. In malignant melanoma 2/3 of the patients in relapse have elevated beta2m levels.
多种标志物已被用于乳腺癌和恶性黑色素瘤的监测,包括癌胚抗原(CEA)、β2-微球蛋白(β2m)和催乳素。监测的双重目的是检测早期复发或转移以及监测治疗情况。在乳腺癌中,92%有骨转移的患者CEA或β2m水平升高。在恶性黑色素瘤中,2/3复发患者的β2m水平升高。