Chugani H T
Department of Pediatrics, UCLA School of Medicine.
Clin Perinatol. 1993 Jun;20(2):395-409.
Positron emission tomography (PET) is an imaging technique that allows local chemical and physiologic functions in various body organs to be measured. Studies of local cerebral glucose metabolism in infants and children using PET have provided important information on human brain functional development and plasticity. In the neonate, PET studies have provided important clues into the pathophysiology of hypoxic-ischemic injury. Patterns of cerebral glucose utilization in various clinical subtypes of cerebral palsy associated with perinatal brain injury are discussed and contrasted to metabolic patterns seen in cerebral palsy without clear etiology. Expanding PET technology provides a new approach that holds great promise in the diagnosis and management of brain disorders affecting the neonate.
正电子发射断层扫描（PET）是一种成像技术，可用于测量身体各器官的局部化学和生理功能。利用PET对婴幼儿局部脑葡萄糖代谢进行的研究，为人类大脑功能发育和可塑性提供了重要信息。在新生儿中，PET研究为缺氧缺血性损伤的病理生理学提供了重要线索。本文讨论了与围产期脑损伤相关的各种临床亚型脑瘫的脑葡萄糖利用模式，并与病因不明的脑瘫的代谢模式进行了对比。不断发展的PET技术提供了一种新方法，在影响新生儿的脑部疾病的诊断和管理方面具有巨大潜力。
