Rice-Evans C A, Diplock A T
Division of Biochemistry, United Medical School, Guy's Hospital, London.
Free Radic Biol Med. 1993 Jul;15(1):77-96. doi: 10.1016/0891-5849(93)90127-g.
There is evidence that free radical damage contributes to the aetiology of many chronic health problems such as emphysema, cardiovascular and inflammatory diseases, cataracts, and cancer. In this review we are not concerned with tissue damage in vivo induced directly by radicals from exogenous sources, such as air pollutants and tobacco smoke, high-pressure oxygen, irradiation, or through the metabolism of certain solvents, drugs, and pesticides. Rather, we address some of the disease states associated with increased oxidative stress from endogenous sources and the possible therapeutic advantage of the antioxidant treatment. This raises the question of the antioxidant status of individuals and its role in protection against amplification of certain disease processes. We have chosen to concentrate mainly on coronary heart disease, reperfusion injury, and organ storage for transplantation.
有证据表明，自由基损伤在许多慢性健康问题的病因中起作用，如肺气肿、心血管疾病、炎症性疾病、白内障和癌症。在本综述中，我们不关注外源性来源的自由基直接在体内引起的组织损伤，如空气污染物和烟草烟雾、高压氧、辐射，或通过某些溶剂、药物和农药的代谢产生的自由基。相反，我们讨论一些与内源性氧化应激增加相关的疾病状态以及抗氧化治疗可能的治疗优势。这就提出了个体抗氧化状态及其在预防某些疾病过程放大中的作用的问题。我们选择主要集中讨论冠心病、再灌注损伤和器官移植保存。
