使用H2(15)O正电子发射断层扫描技术测量人体静息脑血流量的可重复性。
Reproducibility of resting cerebral blood flow measurements with H2(15)O positron emission tomography in humans.
作者信息
Matthew E, Andreason P, Carson R E, Herscovitch P, Pettigrew K, Cohen R, King C, Johanson C E, Paul S M
机构信息
Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
出版信息
J Cereb Blood Flow Metab. 1993 Sep;13(5):748-54. doi: 10.1038/jcbfm.1993.95.
Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H2(15)O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean +/- SD) for the first (40.3 +/- 6.4) and second (39.3 +/- 6.5) measurements was not significantly different (mean % difference 2.3 +/- 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.
使用H2(15)O正电子发射断层扫描技术，对25名正常志愿者进行了两次连续的静息脑血流量（CBF）测量。第一次测量的全脑绝对血流量（WBBF；ml 100 g-1 min-1，平均值±标准差）为（40.3±6.4），第二次测量为（39.3±6.5），两者无显著差异（平均百分比差异为2.3±8.7）。感兴趣区域分析显示，绝对局部脑血流量（rCBF）和归一化（rCBF/WBBF）rCBF均无显著差异。左右差异也不显著。这些数据证明了正常人类静息CBF测量的可重复性。
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