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如何运营一个“脑库”?“脑库”的临床及机构要求。

How to run a "brain bank"? Clinical and institutional requirements for "brain banking".

作者信息

Jendroska K, Patt S, Jänisch W, Cervos-Navarro J, Poewe W

机构信息

Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Federal Republic of Germany.

出版信息

J Neural Transm Suppl. 1993;39:71-5.

PMID:8360666
Abstract

"Brain Banking" or prospective sampling of tissues relevant to the study of neurological disease is a complex task which needs organization at various levels of operation such as the establishment of a donor system, recruitment of clinical assessment centres, establishment of standardized assessment protocols, the inauguration of logistic structures for brain removal and transport to the bank, proper storage of patient data and tissues, histological verification of the disease and availability of tissue and clinical data to researchers. This effort certainly promises to bear fruit since there is a striking lack of precise prospective studies into etiology and pathogenesis in most neurological diseases especially in the field of the neurodegenerative diseases.

摘要

“脑库建设”,即对与神经疾病研究相关的组织进行前瞻性采样,是一项复杂的任务,需要在多个操作层面进行组织协调,比如建立捐赠者体系、招募临床评估中心、制定标准化评估方案、设立脑部移除及运往脑库的后勤架构、妥善存储患者数据和组织、对疾病进行组织学验证以及向研究人员提供组织和临床数据。鉴于在大多数神经疾病尤其是神经退行性疾病领域,对病因和发病机制的精确前瞻性研究严重匮乏,这项工作有望取得成果。

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