Kubota Y, Sato H, Koshimoto C, Takahashi S
Division of Comparative Radiotoxicology, National Institute of Radiological Sciences, Chiba, Japan.
J Radiat Res. 1993 Jun;34(2):157-63. doi: 10.1269/jrr.34.157.
Cross-placental transfer of 239Pu from the mother to fetus was studied in C3H mice. The activity of 239Pu in the conceptus was measured 24 hrs after the intravenous injection of 239Pu citrate on days 10.5 to 16.5 of gestation. More 239Pu was transferred to the conceptus when the plutonium was administered in the later stages of gestation; 0.12% of the injected dose per conceptus on day 10.5 and 1.3% on day 16.5. In all the gestational stages examined, the yolk sac and decidua contained more than 89% of the total activity distributed in the conceptus. The concentration of 239Pu in the yolk sac was about two orders of magnitude greater than that in the fetus. The 239Pu concentration in the maternal liver decreased with the gestational stage. In the early gestational stages the concentration in the maternal liver was greater than that in the yolk sac; but, this relationship was reversed in the later stages.
在C3H小鼠中研究了239Pu从母体到胎儿的胎盘转运。在妊娠第10.5至16.5天静脉注射柠檬酸钚24小时后，测量了胎体中239Pu的活性。当在妊娠后期给予钚时，更多的239Pu被转运到胎体中；在第10.5天每个胎体注射剂量的0.12%，在第16.5天为1.3%。在所有检查的妊娠阶段，卵黄囊和蜕膜所含活性超过胎体中分布的总活性的89%。卵黄囊中239Pu的浓度比胎儿中的浓度大约高两个数量级。母体肝脏中239Pu的浓度随妊娠阶段而降低。在妊娠早期，母体肝脏中的浓度高于卵黄囊中的浓度；但是，在后期这种关系发生了逆转。
