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[支气管哮喘的支气管激发试验]

[Bronchial provocation test in bronchial asthma].

作者信息

Fujimura M, Kamio Y, Hashimoto T

机构信息

3rd Department of Internal Medicine, Kanazawa University School of Medicine.

出版信息

Rinsho Byori. 1993 Feb;41(2):154-9.

PMID:8361017
Abstract

Methacholine provocation test, bronchial reversibility test, aspirin inhalation test, and cough provocation test have been performed at our institute to examine pathophysiology and to diagnose bronchial diseases. Bronchial responsiveness to methacholine correlated to baseline pulmonary functions, especially to % predicted value of forced expiratory volume in 1 second (%FEV1) in asthma and sinobronchial syndrome. Bronchial reversibility was greater with beta 2-agonists than with muscarinic antagonists in asthma while it was less with beta 2-agonists than with muscarinic antagonists in sinobronchial syndrome. Our protocol for aspirin inhalation test consists of a screening test and threshold measurement test and is useful for diagnosis of analgesics-induced asthma. Capsaicin provocation test to measure airway cough receptor sensitivity is used to diagnose chronic cough.

摘要

我院已开展了乙酰甲胆碱激发试验、支气管可逆性试验、阿司匹林吸入试验和咳嗽激发试验,以研究病理生理学并诊断支气管疾病。乙酰甲胆碱的支气管反应性与基线肺功能相关,尤其是与哮喘和鼻支气管综合征中一秒用力呼气量(%FEV1)的预测值百分比相关。在哮喘中,β2受体激动剂的支气管可逆性大于毒蕈碱拮抗剂,而在鼻支气管综合征中,β2受体激动剂的支气管可逆性小于毒蕈碱拮抗剂。我们的阿司匹林吸入试验方案包括筛查试验和阈值测量试验,有助于诊断镇痛药诱发的哮喘。用于测量气道咳嗽受体敏感性的辣椒素激发试验用于诊断慢性咳嗽。

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