Tohda Y, Kubo H, Fukuoka M, Nakajima S
Fourth Department of Internal Medicine, Kinki University.
Nihon Rinsho. 1996 Nov;54(11):2903-7.
Asthma patients have bronchial hyperreactivity compared with normal subjects. The pathophysiological characteristics of bronchial asthma show the reversible bronchial obstruction (air-flow limitation) caused by several physical and chemical stimuli. Thus, it is important to verify the bronchial responsiveness for diagnosis of bronchial asthma. Function testing of bronchial responsiveness is one of the bronchial reactivity tests which is important for the diagnosis of bronchial asthma as well as the judgment of severity, therapeutic effect and the differential diagnosis. Function testing of bronchial responsiveness consists of 2 major parts : 1) standard method of acetylcholine or histamine inhalation test 2) direct-writing recorder of the dose-response curves of the airway to methacholine test (Astograph).
与正常受试者相比，哮喘患者具有支气管高反应性。支气管哮喘的病理生理特征表现为由多种物理和化学刺激引起的可逆性支气管阻塞（气流受限）。因此，验证支气管反应性对于支气管哮喘的诊断很重要。支气管反应性的功能测试是支气管反应性测试之一，对于支气管哮喘的诊断以及严重程度判断、治疗效果和鉴别诊断都很重要。支气管反应性的功能测试包括两个主要部分：1）乙酰胆碱或组胺吸入试验的标准方法；2）气道对乙酰甲胆碱试验（呼吸感应容积描记仪）剂量反应曲线的直接记录器。
