Psuja P, Tokarz A, Turowiecka Z, Sowier J, Zawilska K
Kliniki Hematologii Instytutu Chorób Wewnetrznych.
Pol Tyg Lek. 1993;48(5-6):105-8.
Heparin was administered to 113 patients at risk of thrombosis classified to abdominal surgery either alone (subcutaneously or in inhalation) or in combination with anabolic steroid (nandrolone). No pharmaco-prophylaxis was used in 10 patients. On the day of surgery, heparin activated plasma fibrinolytic activity, prior to an introduction to anesthesia. Measurements of euglobulins clot lysis have shown an increase in endogenous fibrinolytic activity dependent and independent on Hageman's factor and an increase in exogenous fibrinolysis, tested after venous stasis was produced. Heparin had profibrinolytic activity, stimulating plasminogen activators in the blood plasma without the signs of hyperplasminemia. Fibrinolytic system response was the same following subcutaneous injection and heparin inhalations. Administration of heparin combined with anabolic steroid has no additional effect on plasma fibrinolytic activity.
对113例有血栓形成风险的患者使用了肝素，这些患者被归类为接受腹部手术，肝素单独使用（皮下注射或吸入）或与合成代谢类固醇（诺龙）联合使用。10例患者未进行药物预防。在手术当天，在引入麻醉之前，肝素激活了血浆纤维蛋白溶解活性。优球蛋白凝块溶解的测量显示，内源性纤维蛋白溶解活性增加，其依赖和不依赖于哈格曼因子，并且在外源性纤维蛋白溶解方面有所增加，这是在产生静脉淤滞后进行测试的。肝素具有纤维蛋白溶解前活性，刺激血浆中的纤溶酶原激活剂，而没有高纤溶酶血症的迹象。皮下注射和吸入肝素后，纤维蛋白溶解系统的反应相同。肝素与合成代谢类固醇联合使用对血浆纤维蛋白溶解活性没有额外影响。
