Sasaki C T, Suzuki M, Horiuchi M
Arch Otolaryngol. 1977 Mar;103(3):138-43. doi: 10.1001/archotol.1977.00780200064005.
An investigation of laryngeal reflex maturation was undertaken in the dog to identify its period of most rapid postnatal differentiation. The canine model was selected because of its laryngeal reflex similarity to that of the human being. Observations in the dog indicate maximum differentiation to occur 1 to 1 1/2 months postnatally, based on measurements of recurrent laryngeal nerve myelination and conduction velocity. Latency and threshold analyses of evoked laryngeal responses additionally confirm this viewpoint. The importance of these observations rests in an understanding of developmental upper respiratory tract mechanisms that may be chronologically related to causes of fatal ventilatory events producing unexplained infant death. Such a correlation, requiring further confirmation, is based on the assumption that a critical period of most rapid development allows a transient susceptibility to noxious influences that can cause a disruption in organ function and even death of that organism itself.
为确定喉反射在出生后分化最快的时期，对犬进行了喉反射成熟度的研究。选择犬类模型是因为其喉反射与人类相似。基于喉返神经髓鞘形成和传导速度的测量，对犬的观察表明，出生后1至1个半月会发生最大程度的分化。对诱发喉反应的潜伏期和阈值分析进一步证实了这一观点。这些观察结果的重要性在于有助于理解发育中的上呼吸道机制，这些机制可能与导致不明原因婴儿死亡的致命通气事件的病因在时间上相关。这种相关性尚需进一步证实，其基于这样一种假设，即发育最快的关键时期会使机体对有害影响产生短暂的易感性，从而可能导致器官功能紊乱甚至机体自身死亡。
