罗红霉素对16种非典型分枝杆菌的体外活性及pH对其放射性测定最低抑菌浓度的影响。
In vitro activity of roxithromycin against 16 species of atypical mycobacteria and effect of pH on its radiometric MICs.
作者信息
Rastogi N, Goh K S, Bryskier A
机构信息
Unité de la Tuberculose et des Mycobactéries, Institut Pasteur, Paris, France.
出版信息
Antimicrob Agents Chemother. 1993 Jul;37(7):1560-2. doi: 10.1128/AAC.37.7.1560.
Abstract
The antimycobacterial spectrum of roxithromycin, a semisynthetic 14-membered ring macrolide, was determined against 28 strains belonging to 16 species of atypical mycobacteria by measuring radiometric MICs by BACTEC methodology at two different pH values, i.e., 6.8 and 7.4. The MICs obtained at pH 7.4 were 1 to 2 dilutions lower or more than those obtained at pH 6.8 for some of the species. Roxithromycin possessed promising MICs against such potential pathogens as the Mycobacterium avium complex, M. scrofulaceum, M. szulgai, M. malmoense, M. xenopi, M. marinum, M. kansasii, and rare pathogens like M. chelonei subsp. chelonei and M. chelonei subsp. abscessus but not against M. simiae. Roxithromycin showed lower MICs against M. fortuitum var. peregrinum than M. fortuitum var. fortuitum.
摘要
通过采用BACTEC方法在两个不同pH值（即6.8和7.4）下测量放射性最低抑菌浓度（MIC），测定了半合成14元环大环内酯类药物罗红霉素对属于16种非典型分枝杆菌的28株菌株的抗分枝杆菌谱。对于某些菌种，在pH 7.4时获得的MIC比在pH 6.8时低1至2倍稀释度或更低。罗红霉素对诸如鸟分枝杆菌复合群、瘰疬分枝杆菌、苏尔加分枝杆菌、马尔默分枝杆菌、偶发分枝杆菌、海分枝杆菌、堪萨斯分枝杆菌等潜在病原体以及像龟分枝杆菌龟亚种和龟分枝杆菌脓肿亚种等罕见病原体具有良好的MIC，但对猿分枝杆菌无效。罗红霉素对偶然分枝杆菌流浪变种的MIC比对偶然分枝杆菌偶然变种的MIC低。
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