[慢性支气管阻塞性哮喘患儿的淋巴细胞亚群]

[Lymphocyte subpopulation in asthmatic children with chronic bronchial obstruction].

作者信息

Murayama N, Kameda M, Takamatsu I, Inoue T, Doi S, Toyoshima K

机构信息

Department of Pediatric Allergy, Osaka Prefectural Habikino Hospital.

出版信息

Arerugi. 1993 Jul;42(7):817-21.

PMID:8363433

Abstract

Lymphocyte subpopulations in peripheral blood were examined in asthmatic children, using fluorescent monoclonal antibodies. The patients were divided into three groups: Group I, no attack (FEV1.0% > or = 80% group), Group II, no attack (FEV1.0% < 80% group) and Group III, asthmatic attack group. The percentage of CD3HLADR/CD3 in the Group II and Group III were 5.58 +/- 3.59 and 5.44 +/- 4.34, respectively, which were significantly higher than that in the Group I subjects (2.70 +/- 2.17). This finding suggests that the patients with long lasting bronchial obstruction may have chronic inflammation in the airway even in the remission stage of asthmatic attacks.

摘要

采用荧光单克隆抗体检测哮喘患儿外周血淋巴细胞亚群。将患者分为三组：第一组，无发作（FEV1.0%≥80%组）；第二组，无发作（FEV1.0%＜80%组）；第三组，哮喘发作组。第二组和第三组中CD3HLADR/CD3的百分比分别为5.58±3.59和5.44±4.34，显著高于第一组受试者（2.70±2.17）。这一发现表明，即使在哮喘发作的缓解期，长期存在支气管阻塞的患者气道中可能也存在慢性炎症。