Lang P D, Degott M, Vollmar J
Atherosclerosis. 1977 Jan;26(1):29-39. doi: 10.1016/0021-9150(77)90137-x.
In order to study the relationship between the fatty acid composition of adipose tissue and coronary heart disease (CHD), 34 consecutive male patients with acute myocardial infarction and 33 hospitalized men free of CHD were compared. Patients with diabetes mellitus, endocrine disorders, liver and kidney diseases, recent changes in body weight and deviations from the "normal", customary diet were exlcuded. A statistically significant difference between the two groups was observed only in stearic acid, its proportion being lower in CHD patients (3.25% vs. 4.13%). Using multivariate discriminant analysis, age discriminated best between the groups, followed by stearic acid. The signs observed were positive for the former and negative for the latter. All other acids, relative body weight, and skinfold measurements did not significantly contribute to the discrimination. Age did not correlate with the proportion of stearic acid. Blood lipids from samples taken within 24 h of admission did not significantly differ between the groups. Three months later they had risen considerably in the infarct patients. The metabolic basis of the relationship between CHD and stearic acid is not clear at present. Additional studies are necessary to substantiate the importance of this acid as an indicator of CHD.
为了研究脂肪组织的脂肪酸组成与冠心病（CHD）之间的关系，对34例连续的急性心肌梗死男性患者和33例无冠心病的住院男性进行了比较。排除患有糖尿病、内分泌紊乱、肝肾疾病、近期体重变化以及偏离“正常”习惯饮食的患者。两组之间仅在硬脂酸方面观察到统计学上的显著差异，冠心病患者中硬脂酸的比例较低（3.25%对4.13%）。使用多变量判别分析，年龄在两组之间的区分效果最佳，其次是硬脂酸。观察到的迹象前者为正，后者为负。所有其他酸、相对体重和皮褶测量对区分没有显著贡献。年龄与硬脂酸的比例无关。入院后24小时内采集的样本中的血脂在两组之间没有显著差异。三个月后，梗死患者的血脂显著升高。目前冠心病与硬脂酸之间关系的代谢基础尚不清楚。需要进一步的研究来证实这种酸作为冠心病指标的重要性。
