人体胸骨后脂肪组织和血浆脂质中的反式脂肪酸含量：与血管造影记录的冠心病的关系。

Contents of trans-fatty acids in human substernal adipose tissue and plasma lipids: relation to angiographically documented coronary heart disease.

作者信息

Fritsche J, Steinhart H, Kardalinos V, Klose G

机构信息

Institute of Biochemistry and Food Chemistry, Department of Food Chemistry, Grindelallee 117, D-20146 Hamburg, Germany.

出版信息

Eur J Med Res. 1998 Aug 18;3(8):401-6.

PMID:9707524

Abstract

The contents of trans-fatty acid (TFA) isomers of human substernal adipose tissue and plasma lipids (cholesterol esters, triacylglycerols, phospholipids), obtained from patients with angiographically documented coronary heart disease (CHD group; n = 24) and from controls (excluded CHD; n = 25), were determined by capillary gas chromatography. No significant difference (P <0.05) could be observed between cases (2.59 +/- 33%) and controls (2.79 +/- 0.76%) with regard to adipose tissue total TFA contents (expressed as proportion of all identified fatty acid methyl esters). The total adipose tissue TFA content reflected the dietary TFA intake, which was estimated by dietary questionnaires. Both groups showed significant differences in several isomeric plasma lipid TFA. Cases generally had a tendency to lower individual TFA contents.

摘要

通过毛细管气相色谱法测定了经血管造影证实患有冠心病患者（冠心病组；n = 24）和对照组（排除冠心病；n = 25）的人体胸骨后脂肪组织以及血浆脂质（胆固醇酯、三酰甘油、磷脂）中反式脂肪酸（TFA）异构体的含量。就脂肪组织总TFA含量而言（以所有鉴定出的脂肪酸甲酯的比例表示），病例组（2.59±33%）和对照组（2.79±0.76%）之间未观察到显著差异（P<0.05）。脂肪组织总TFA含量反映了通过饮食问卷估计的饮食TFA摄入量。两组在几种异构体血浆脂质TFA方面存在显著差异。病例组个体TFA含量总体上有降低的趋势。