Newman D L, Batten J R, Bowden N L
Atherosclerosis. 1977 Feb;26(2):195-204. doi: 10.1016/0021-9150(77)90102-2.
The influence of abdominal aortic stenosis on the uptake of the protein-binding trypan blue dye and 131I human serum albumin (HSA) has been studied. The major change was a region of high uptake proximal to the stenosis, returning to normal by the level of the renal arteries. There was reduced uptake distal to the stenosis, apart from occasional small areas of high uptake probably due to turbulence. The increase in uptake immediately proximal to the stenosis was dependent on the severity and duration of the stenosis. Removal of the stenosis immediately before the injection of dye and 131I-HSA still resulted in elevated uptake in the proximal region. Some haemodynamic modifications resulting from a stenosis are described. It is suggested that the most satisfactory haemodynamic explanation of the observed uptake change is a proximal increase in oscillatory pressure/strain. The relevance of these findings to atherosclerotic development at and above arterial junctions is discussed.
研究了腹主动脉狭窄对蛋白结合锥虫蓝染料和131I人血清白蛋白（HSA）摄取的影响。主要变化是狭窄近端有一个高摄取区域，到肾动脉水平恢复正常。狭窄远端摄取减少，偶尔有因湍流导致的小面积高摄取区域除外。狭窄近端紧邻处摄取的增加取决于狭窄的严重程度和持续时间。在注射染料和131I-HSA之前立即去除狭窄，近端区域的摄取仍会升高。描述了由狭窄引起的一些血流动力学改变。有人提出，对观察到的摄取变化最令人满意的血流动力学解释是振荡压力/应变在近端增加。讨论了这些发现与动脉交界处及以上部位动脉粥样硬化发展的相关性。
