Batten J R, Newman D L, Bowden N L
Atherosclerosis. 1977 Oct;28(2):101-9. doi: 10.1016/0021-9150(77)90148-4.
The uptake of trypan blue and [131I]human serum albumin (HSA) has been studied in the dog's abdominal aorta between 1 and 42 days after removal of an experimental stenosis (approximately 90%) applied 1 week previously. Previous work has shown that when the stenosis was present during circulation of these markers, their uptake was increased immediately proximal to the stenosis decreasing to normal by the renal artery level. Distal to the stenosis uptake was reduced apart from small areas of high uptake probably due to turbulent jet impacts. Within the stenosed section the uptake was normal. In this present study it was found that, after removal of the stenosis, proximal uptake initially remained elevated, returning to normal after approximately 15 days whilst the distal uptake returned to normal after approximately 10 days. In the previously stenosed section uptake was increased markedly following the release of the stenosis but returned to normal within approximately 20 days. The relationship of these findings to alterations in the local haemodynamic state and to possible changes in endothelial morphology are discussed.
在去除一周前施加的实验性狭窄（约90%）后的1至42天内，对犬腹主动脉中锥虫蓝和[131I]人血清白蛋白（HSA）的摄取情况进行了研究。先前的研究表明，当这些标志物循环时存在狭窄，其摄取在狭窄近端立即增加，并在肾动脉水平降至正常。除了可能由于湍流射流冲击导致的小面积高摄取区域外，狭窄远端的摄取减少。在狭窄段内，摄取正常。在本研究中发现，去除狭窄后，近端摄取最初仍保持升高，约15天后恢复正常，而远端摄取约10天后恢复正常。在先前狭窄的节段，狭窄解除后摄取明显增加，但约20天内恢复正常。讨论了这些发现与局部血流动力学状态改变以及内皮形态可能变化的关系。
