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抗原呈递、免疫记忆丧失与艾滋病

Antigen presentation, loss of immunological memory and AIDS.

作者信息

Helbert M R, L'age-Stehr J, Mitchison N A

机构信息

Robert Koch Institut des Bundesgesundheitsamtes, Berlin, Germany.

出版信息

Immunol Today. 1993 Jul;14(7):340-4. doi: 10.1016/0167-5699(93)90232-A.

DOI:10.1016/0167-5699(93)90232-A
PMID:8363722
Abstract

A key factor causing immunodeficiency in HIV infection seems to be defective antigen presentation. Consequently, CD4+ T-cell populations, initially those expressing CD45RO, decrease in number not because of their destruction, but because they fail to expand in response to antigenic stimulation. This view implies that it would be mistaken to aim therapies only at correcting T-cell function or preventing infection of T cells.

摘要

导致HIV感染免疫缺陷的一个关键因素似乎是抗原呈递缺陷。因此，CD4+ T细胞群体，最初是那些表达CD45RO的细胞，数量减少并非因为它们被破坏，而是因为它们无法对抗原刺激作出反应而扩增。这种观点意味着，仅将治疗目标设定为纠正T细胞功能或预防T细胞感染是错误的。

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