Burkhardt A, Seifert G
Dtsch Med Wochenschr. 1977 Feb 18;102(7):223-9. doi: 10.1055/s-0028-1104869.
656 cases of oral leukoplakia were analysed according to macroscopic aspects, microscopic growth patterns and histologicalcytological differentiation, and the relationship to cancer of the oral cavity was studied. Homogeneous and speckled leukoplakia can be distinguished macroscopically, while flat (70%), papillary-endophytic (22%) and papillomatous-exophytic (8%) types can be distinguished by their growth pattern. Histological-cytological characteristics consist of epithelial hyperplasia (hyperkeratosis with ortho- or parakeratosis; akanthosis) and epithelial dysplasia (dyskeratosis, basal-cell hyperplasia, loss of polar arrangement of the basal cells, cell polymorphism, increased mitosis rate). No or little dysplasia was demonstrated in 74% of leukoplakias, moderate in 17% and marked in 6%. Carcinoma-in-situ, defined as high-grade dysplasia with additional loss of epithelial layering, was found in 3%. Precancerous leukoplakia (in almost 10% of cases, counting high-grade dysplasias and carcinoma-in-situ) must be delineated as a special group. Numerous correlations were found between dysplastic leukoplakias and oral cavity cancer as regards localisation, age and sex distribution. In the various leukoplakia forms there was an increased incidence of marked stroma reactions and of Candida colonisation with increased degrees of dysplasia.
对656例口腔白斑病例，根据其宏观表现、微观生长模式及组织学 - 细胞学分化进行分析，并研究其与口腔癌的关系。均质型和斑点型白斑可通过宏观表现区分，而扁平型（70%）、乳头内生型（22%）和乳头外生型（8%）可通过其生长模式区分。组织学 - 细胞学特征包括上皮增生（伴有正角化或不全角化的过度角化；棘层增厚）和上皮发育异常（异常角化、基底细胞增生、基底细胞极性排列丧失、细胞多形性、有丝分裂率增加）。74%的白斑未显示发育异常或仅有轻微发育异常，17%为中度发育异常，6%为重度发育异常。原位癌定义为伴有上皮分层额外丧失的高度发育异常，占3%。癌前白斑（将高度发育异常和原位癌计算在内，几乎占病例的10%）必须作为一个特殊群体加以界定。在发育异常的白斑与口腔癌之间，在部位、年龄和性别分布方面发现了许多相关性。在各种白斑形式中，随着发育异常程度的增加，显著的基质反应和念珠菌定植的发生率升高。
