Lipsy R J, Smith G H, Maloney M E
Department of Pharmacy Practice, College of Pharmacy, University Medical Center, Tucson, AZ 85724.
Ann Pharmacother. 1993 Jul-Aug;27(7-8):856-61. doi: 10.1177/106002809302700706.
To describe the development, implementation, and use of an antimicrobial order form. The article provides the design of the form and the rationale for including key aspects, and a report of the authors' experiences with the form over a three-year period. An analysis of compliance with the form and its impact on selected prescribing practices is also presented.
Three thousand five hundred antimicrobial orders in four discrete sets over a three-year period were analyzed to assess compliance and characterize prescribing patterns with respect to duration of therapy and dosing frequency.
The setting of the study was a 300-bed, university-affiliated, tertiary-care, teaching hospital.
Analysis of the forms was organized into the following sections: (1) compliance with use of the form, (2) duration of therapy, and (3) impact on antimicrobial dosing intervals.
Use of the form was essentially 100 percent. Seventy-eight percent of the forms had all required data elements completed in the period following implementation; this fell to 67 percent at the end of three years. Duration of surgical prophylaxis went beyond the recommended 24 hours in 10 percent of all cases in period 1, and in 18, 8, and 4 percent in periods 2, 3, and 4, respectively. Declines in inappropriate dosing frequency were seen with cefazolin (from 14 to 2.3 percent), ceftriaxone (from 23 to 4 percent), cefuroxime (from 21 to 0 percent), and clindamycin (from 43 to 7 percent).
Our experience with implementation and use of the form was very positive. Significant difficulties with compliance were not encountered. Benefits of the form included reductions in the duration of surgical prophylaxis and in the frequency of inappropriate dosing intervals.
描述抗菌药物医嘱单的开发、实施及使用情况。本文介绍了该表单的设计以及纳入关键内容的基本原理,并报告了作者在三年期间使用该表单的经验。还对表单的依从性及其对特定处方实践的影响进行了分析。
对三年期间四个不同时间段的3500份抗菌药物医嘱进行分析,以评估依从性,并就治疗持续时间和给药频率来描述处方模式。
该研究在一家拥有300张床位、与大学相关的三级护理教学医院进行。
对表单的分析分为以下几个部分:(1)表单使用的依从性,(2)治疗持续时间,(3)对抗菌药物给药间隔的影响。
表单使用率基本达到100%。在实施后的一段时间内,78%的表单填写了所有必填数据项;三年结束时,这一比例降至67%。在第1阶段,10%的所有手术预防病例的预防时间超过了推荐的24小时,在第2、3和4阶段,这一比例分别为18%、8%和4%。头孢唑林(从14%降至2.3%)、头孢曲松(从23%降至4%)、头孢呋辛(从21%降至0%)和克林霉素(从43%降至7%)的不适当给药频率有所下降。
我们在该表单的实施和使用方面的经验非常积极。未遇到明显的依从性困难。该表单的益处包括缩短手术预防时间和减少不适当给药间隔的频率。