Havsteen B H, Garcia-Moreno M, Valero E, Manjabacas M C, Varón R
Biochemisches Institut, Universität zu Kiel, Germany.
Bull Math Biol. 1993 May;55(3):561-83. doi: 10.1007/BF02460651.
A general model of zymogen activation is proposed and explicit kinetic equations for the time courses of the various species and products involved are given. These equations are valid for the whole course of the reaction and therefore for both the transient phase and the steady state. This model is sufficiently general to include mechanisms possessing one or more steps of zymogen activation besides possible steps of inhibition (reversible or irreversible) or inactivation.
提出了一种酶原激活的通用模型，并给出了所涉及的各种物质和产物随时间变化的显式动力学方程。这些方程适用于反应的整个过程，因此适用于瞬态阶段和稳态。该模型足够通用，除了可能的抑制（可逆或不可逆）或失活步骤外，还包括具有一个或多个酶原激活步骤的机制。
