用于预防结肠癌的非甾体抗炎药。
Nonsteroidal anti-inflammatory drugs for the prevention of colon cancer.
作者信息
Turner D, Berkel H J
机构信息
Division of Epidemiology and Preventive Oncology, Alberta Cancer Board, Edmonton.
出版信息
CMAJ. 1993 Sep 1;149(5):595-602.
OBJECTIVE
To summarize the results of animal and human studies of the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on neoplastic growth in the colon and to outline the possible mechanisms involved.
DATA SOURCES
Research articles published in English before June 1992 were identified from MEDLINE.
STUDY SELECTION
Nine articles on the polyp-cancer sequence were reviewed, 8 on the apparent pathophysiologic aspects of tumour inhibition by NSAIDs and 22 on animal and human research into the effect of NSAIDs on colon carcinogenesis.
RESULTS
The results of animal and human research into the anticarcinogenic effect of NSAIDs suggest that the drugs are effective in preventing tumour growth in the colon.
CONCLUSIONS
Intervention studies in humans are necessary to elucidate the therapeutic possibilities of NSAIDs, particularly in populations at increased risk for the development of colon cancer.
目的
总结关于非甾体抗炎药（NSAIDs）对结肠肿瘤生长影响的动物和人体研究结果，并概述其中可能涉及的机制。
资料来源
从MEDLINE中检索出1992年6月以前发表的英文研究文章。
研究选择
对9篇关于息肉-癌序列的文章、8篇关于NSAIDs抑制肿瘤的明显病理生理方面的文章以及22篇关于NSAIDs对结肠癌发生影响的动物和人体研究文章进行了综述。
结果
对NSAIDs抗癌作用的动物和人体研究结果表明，这些药物在预防结肠肿瘤生长方面是有效的。
结论
有必要在人体中进行干预研究，以阐明NSAIDs的治疗潜力，特别是在结肠癌发病风险增加的人群中。
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