幽门螺杆菌与分化型早期胃癌的关联。
The association of Helicobacter pylori with differentiated-type early gastric cancer.
作者信息
Tatsuta M, Iishi H, Okuda S, Taniguchi H, Yokota Y
机构信息
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
出版信息
Cancer. 1993 Sep 15;72(6):1841-5. doi: 10.1002/1097-0142(19930915)72:6<1841::aid-cncr2820720608>3.0.co;2-i.
BACKGROUND
Recent studies have indicated that infection with Helicobacter pylori is closely associated with increased risk for gastric cancer. Previous studies, however, usually have been made on cases of advanced gastric cancer.
METHODS
The Congo red-methylene blue test was performed on 19 healthy subjects, 24 patients with early gastric cancer of differentiated type, and 17 patients with early cancer of undifferentiated type. H. pylori infection was examined by culture of biopsy specimens obtained from noncancerous antral mucosa.
RESULTS
H. pylori was detected in 19 (79%) of 24 patients with differentiated-type early gastric cancer, but in only 5 (29%) of 17 patients with undifferentiated-type early gastric cancer; this difference was statistically significant. It also was detected significantly more frequently in patients with differentiated cancers than in healthy subjects.
CONCLUSIONS
H. pylori infection was closely associated with differentiated-type gastric cancers, but not with undifferentiated types.
背景
近期研究表明，幽门螺杆菌感染与胃癌风险增加密切相关。然而，以往研究通常针对进展期胃癌病例。
方法
对19名健康受试者、24例分化型早期胃癌患者和17例未分化型早期癌患者进行刚果红-亚甲蓝试验。通过培养取自非癌性胃窦黏膜的活检标本检测幽门螺杆菌感染。
结果
24例分化型早期胃癌患者中有19例（79%）检测到幽门螺杆菌，而17例未分化型早期胃癌患者中仅5例（29%）检测到；此差异具有统计学意义。在分化型癌症患者中检测到幽门螺杆菌的频率也显著高于健康受试者。
结论
幽门螺杆菌感染与分化型胃癌密切相关，但与未分化型无关。
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