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亲表皮转移性黑色素瘤。当前的组织学标准是否足以区分原发性黑色素瘤和转移性黑色素瘤?

Epidermotropic metastatic melanoma. Are the current histologic criteria adequate to differentiate primary from metastatic melanoma?

作者信息

Bengoechea-Beeby M P, Velasco-Osés A, Mouriño Fernández F, Reguilón-Rivero M C, Remón-Garijo L, Casado-Pérez C

机构信息

Department of Plastic Surgery, Hospital General Yagüe, Burgos, Spain.

出版信息

Cancer. 1993 Sep 15;72(6):1909-13. doi: 10.1002/1097-0142(19930915)72:6<1909::aid-cncr2820720619>3.0.co;2-s.

DOI:10.1002/1097-0142(19930915)72:6<1909::aid-cncr2820720619>3.0.co;2-s
PMID:8364867
Abstract

A case is reported of a patient with a lentiginous acral melanoma of the heel that was excised and recurred 3 years later at the margin of the previous scar. After another 3 years, a group of five small lesions appeared in the thigh that were considered to be junctional and epidermotropic metastases. The authors question the current histologic criteria for differentiating junctional and epidermotropic metastases of previous melanomas from multiple primary melanomas. It is concluded that the clinical history is of primary importance in reaching a correct diagnosis; histologic studies are not sufficient.

摘要

报告了1例足跟部雀斑样肢端黑色素瘤患者,该肿瘤被切除,3年后在先前瘢痕边缘复发。又过了3年,大腿出现5个小病灶,被认为是交界性和向表皮性转移灶。作者对目前用于区分既往黑色素瘤的交界性和向表皮性转移灶与多发性原发性黑色素瘤的组织学标准提出质疑。得出的结论是,临床病史对于做出正确诊断至关重要;组织学研究并不充分。

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引用本文的文献

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Epidermotropic metastatic melanoma clinically resembling agminated spitz nevi.临床上类似聚集性斯皮茨痣的亲表皮转移性黑色素瘤。
Ann Dermatol. 2014 Oct;26(5):628-31. doi: 10.5021/ad.2014.26.5.628. Epub 2014 Sep 26.
2
Epidermotropic metastatic melanoma with perilesional depigmentation in an Indian male.一名印度男性患伴有病灶周围色素脱失的亲表皮转移性黑色素瘤。
Indian J Dermatol. 2013 Sep;58(5):396-9. doi: 10.4103/0019-5154.117323.
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Evaluation of the clonal origin of multiple primary melanomas using molecular profiling.使用分子谱分析评估多发性原发性黑色素瘤的克隆起源
J Invest Dermatol. 2009 Aug;129(8):1972-82. doi: 10.1038/jid.2009.4. Epub 2009 Mar 12.