Graham A, Hogg N, Kalyanaraman B, O'Leary V, Darley-Usmar V, Moncada S
Wellcome Research Laboratories, Beckenham, Kent, UK.
FEBS Lett. 1993 Sep 13;330(2):181-5. doi: 10.1016/0014-5793(93)80269-z.
Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of alpha-tocopherol to alpha-tocopherol quinone.
过氧亚硝酸盐是一种氧化剂，可通过超氧化物与一氧化氮在脉管系统中反应形成。它能够修饰氨基酸残基并引发脂质过氧化。在本研究中，我们已表明过氧亚硝酸盐可将低密度脂蛋白转变为一种可被巨噬细胞清道夫受体识别的形式，并且这一过程与蛋白质和脂质的修饰以及α-生育酚氧化为α-生育醌有关。
